Politics/World Affairs: Lenin (for entirely great reasons!)
Medicine/Biology: slightly tangentially, I'd say Freud.
Technology: Not sure about this but would agree it must be someone with links to computers.
Physics: Einstein
Philosophy: (pre WW2) Wittgenstein (post WW2) Deleuze
Literature: James Joyce
Painting or Sculpture: Picasso or Warhol
Music: Elvis
Film: Godard
And finally, who you believe was the single most significant figure of the 20th Century: Lenin.
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