As a kid I read a buttload of Spiderman. These days I have no interest in Marvel or D.C.
My two favorite graphic novels / manga are (and this simultaneously answers your question, chairman of the bored) 'Akira' and 'Lone Wolf and Cub.'
I'm actually surprised no one has mentioned 'Lone Wolf and Cub' yet. The story is amazing, the history is impeccably researched, the characters are great, and the art work is beautiful. Looking back, in the first volume they're clearly breaking into things... the writing, but mostly the art, but it pretty much becomes and remains stellar for the remaining 27 volumes. I alternately wish Ogami Itto was my father, and that Daigoro was my son. You know, like, if I was ever forced to have a kid or if the chick was like "Yeah, I thought I was down with abortions before, but I don't know anymore..." and then ruined both of our lives.
This picture is from the second volume.
