.22 pistols are for rodents and target practice. A good .22 rifle is actually an ideal murder weapon. You don't have to register .22s. The are virtually untraceable. The bullet usually fragments and becomes near impossible to find.
They are still a gun. Even a BB gun can be deadly. But.
a .22 is a weak gun. If I was held at gun point and I could tell it was a .22, I would take my chances and try to disarm the gun(wo)man. a glock .40; however, is a completely different story.
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