I also feel that Life is "pointless" in the long run. And I also believe that the more introspective and observant that a person is, the more likely they are to be depressed/unhappy. Really, life is only as pointless as we let it be (regardless of religious beliefs, etc.)
Over the last year or so (with the help of meds) I've begun looking at life in a more care-free manner. It's like I'm in on a little secret... life is pointless so I'll just do as I please and make myself happy and fulfilled while all these sheep run-around trying to impress and do what they're told is right. Mind you, I'm a reserved and calm person so my idea of being care-free isn't exactly hedonistic... it's just nice to be able to remind myself (and I often have to remind myself) that it truly doesn't matter what kind of impression I make on others. I or they could be dead tomorrow... and what we said or did in the past just won't matter in the long run.
Be happy. Do the things that you enjoy and don't think about things so much. I know it's easier said than done... that's why you have to practice happiness before you can actually live it. Sit on the couch with a significant other, or family member or dear friend or pet, and be warm and watch a favorite movie. Do anything that makes you smile and gets your mind off bullshit. Life may be pointless in the end, but there's still room to enjoy it
